skip to Main Content
The data we are collecting through our flagship project The Heartland Study will someday be used to make a chart like this that maps the relationship between herbicide exposure and health outcomes. What stories will our data tell?

Archived Blog Posts
  • Eaters Deserve More Complete Information About Nutrition and Health Impacts on Food Labels  

    Multiple lines of evidence point to consumer food choices as major contributors to diet-related disease, and poor health and fitness. In a peer-reviewed journal article published today, authors Chuck Benbrook and Robin Mesnage cite studies indicating that “Some 90% of the estimated USD 4.3 trillion in annual health care costs in the US is triggered or made worse by poor food quality and diet-related disease.” Benbrook is the founder and former executive director of the Heartland Health Research Alliance (HHRA). The authors recommend novel metrics on both the nutrient density of food, and how to more accurately and usefully characterize the degree of food processing and its impacts on public health. The article is open access in the journal Foods and entitled “Enhanced Labeling to Promote Consumption of Nutrient Dense Foods and Healthier Diets.” The core nutrient density metric is a ratio: the percent of daily nutrient needs satisfied by a serving of food relative to the percent of a 2000 calorie daily diet taken up by the serving of food. This single metric is unmatched in comprehensively reflecting the nutritional quality of food. A graphic option to convey the metric on packaging is presented in Figure 3 in the new paper: A novel graphic is presented in Figure 5 to which integrates both the nutrient density and food processing metrics and graphics in a single graphic, shown below. The impacts of ultra-processed food (UPF) on public health outcomes is among the hottest topics in nutrition, medical, and public health journals, and media coverage on food quality and health outcomes. At the request of the journal, the authors developed a video abstract that explains the paper’s goals, methods, and key findings and recommendations. The authors conclude their paper with these observations: Transparent and accurate food product-specific ingredient and nutrient composition data should determine the content of nutrition health labeling. Efforts to soften the message should be resisted in light of the overwhelming need for new food labels that help bring about substantial improvements in food nutritional quality and dietary choices. Benbrook and Mesnage’s paper builds on public comments HHRA submitted in response to the US Food and Drug Administration (FDA) proposed rule in 2023 to update the definition of the term “healthy” on food labels. The proposed role would require foods labeled “healthy” to contain minimum amounts of foods recommended by USDA’s Dietary Guidelines, and to limit saturated fat, sodium, added sugar and other less healthy nutrients. Entitled “Food Labeling: Nutrient Content Claims; Definition of Term `Healthy’”, the comments recommended new  nutrition/health messaging on the front of food packaging. Co-authors of comments included the chair of HHRA’s Policy Advisory committee Dr. Kathleen Merrigan, HHRA science advisors, and other experts working on how changes in farming systems and technology can increase the nutritional quality of food: Dr. Hannah Flower, Dr. Donald R. Davis, Dr. David Montgomery and Anne Biklé. In the comments, the authors introduced “NuCal” as a name for their new system. Resources HHRA February 2023 comments to the FDA. Benbrook and Mesnage (2024). Enhanced Labeling to Promote Consumption of Nutrient Dense Foods and Healthier Diets, Foods. https://doi.org/10.3390/foods13213377 Video Abstract: “Enhanced Labeling to Promote Consumption of Nutrient Dense Foods and Healthier Diets”

  • HHRA Weighs in on Key Pesticide Issues Under Review by the National Organic Standards Board

    HHRA and ORG-Tracker, represented by Dr. Chuck Benbrook and Dr. Brian Baker, submitted comments to the Agricultural Marketing Service at the USDA in advance of the National Organic Standards Board (NOSB) meeting in Portland, Oregon, from October 22nd to 24th, 2024. Drs. Benbrook and Baker will both attend the conference and deliver public comments. ORG-Tracker is a project carried out by HHRA. It aggregates pesticide residue data from inspections of organic farms carried out by certifiers. The tables generated by ORG-Tracker utilize the results of certifier testing to compare residue frequency and risk levels to food produced on conventional farms. The team is working to more effectively highlight gaps and challenges faced by certification agencies to answer questions like What crops should we be testing, and where? Is a pesticide residue found in an organic sample likely caused by accident, pesticide drift, or an intentional and illegal application? How can we modify organic programs to better mitigate risk? The comments delivered to the USDA discuss risk-based certification, pesticide residue testing, and policies impacting the incorporation of so-called inert ingredients in the biopesticides approved for use on organic farms. They argue for a more rigorous, comprehensive, and health-focused approach to risk oversight. Regarding residue testing, they advocate for more expansive and effective data aggregation to inform consumers and the organics community. Finally, for inert ingredients, they recommend further review of current policy, including increased transparency of ingredients in pesticide products. Thank you to Drs. Benbrook and Baker for your advocacy and hard work!   The three sets of comments are posted on HHRA’s website as part of our policy program: Comments to the NOSB on the Risk-Based Certification Discussion Document Under Consideration During the October 2024 Meeting in Portland, Oregon Written Comments on the NOSB Discussion Document “Residue Testing for the Global Supply Chain” Comments on the Inert Ingredients in Organic Pesticide Products Proposal dated August 13, 2024   Drs. Benbrook and Baker also submitted and presented comments at the Spring 2024 meeting of the NOSB, which are available on HHRA’s Policy and Regulatory Reform page.

  • Dr. Kimberly Yolton joins HHRA board

    Dr. Yolton is a developmental psychologist and epidemiologist serving as Professor of Pediatrics at Cincinnati Children’s Hospital Medical Center. Her interests include exposures and experiences that may alter a child’s developmental trajectory from infancy through adolescence. She collaborates on research projects on typical child development as well as those focused on the impact of exposures to environmental toxicants, opiates and stress during early development.

  • Paul Hartnett, HHRA’s Executive Director

      Paul Hartnett has served as HHRA’s CFO since our founding . With the departure of Russell King, Paul has now joined the board and Executive Director. We thank Russell for his service and wish him the best in his future endeavors.

  • Heartland Study Enrolls 1,000th Mother-Infant Pair

    July 19, 2024 – In June of this year, the Heartland Study achieved a major milestone, enrolling its 1,000th mother-infant pair. Enrollment is now at 50% of goal. The objective of the Study is to help fill major gaps in our understanding of the impacts of herbicides on maternal and infant health. Currently in Phase 1, the Study is focused on evaluating associations between herbicide concentrations in body fluids and tissue samples from pregnant women and infants, and pregnancy/childbirth outcomes. Phase 2 is designed to evaluate potential associations between herbicide biomarkers and early childhood neurological development. Much appreciation for the mothers enrolled, and the entire Heartland Study Team including scientists, support staff and clinicians for this tremendous achievement, and for our funders to making this work possible. Read more about the study including peer-reviewed studies published in Chemosphere and Agrichemicals at our publications  page. The investment required to conduct this study exceeds $1 million each year. You can support this important work by making a donation here.

Connecting Dots: Musings on What Data Can Teach Us

Apr 6th, 2021
Apr 6th, 2021
The data we are collecting through our flagship project The Heartland Study will someday be used to make a chart like this that maps the relationship between herbicide exposure and health outcomes. What stories will our data tell?

Once in a while two data points are arrayed in a graph, setting off the bright light of insight. A good example appeared in “The Morning,” David Leonhart’s daily New York Times online synopsis of the news of the day.

The chart below appears in his March 12, 2021 newsletter in a section entitled “Follow-up: A Covid Mystery”:

By: The New York Times | Sources: Health agencies and hospitals, C.I.A. World Factbook

Imagine how the dots would move around if the variable “Covid deaths per million residents” were corrected for the quality of each country’s healthcare services and the number of deaths prevented per Covid case.

This chart drives home what public health experts have been stressing throughout the pandemic: Chronic health problems linked to obesity such as hypertension and diabetes dramatically increase the risk of serious Covid infection, sometimes leading to hospitalization and a greatly elevated risk of death.

The power of this graphic arises in part from the underlying accuracy of the data it rests upon. There is little (but some) ambiguity at the national level in data on Covid deaths, and obesity is well defined and an easily tracked indicator of a nation’s health status.

The Heartland Study, HHRA’s flagship project, will assess whether prenatal herbicide exposure levels are increasing the severity or frequency of adverse birth outcomes. Our work is focused on the 13-state Midwest region where herbicide use and exposures are rapidly rising. Our goal is to enroll and bring 2,000 mother-infant pairs (MIPs) through the Heartland Study protocol.

In a few years The Heartland Study team will produce the data needed to produce a graph like the one below, but with 2,000 data points, one for each MIP.

Complex metabolic and physiological dynamics link an individual’s obesity to an adverse Covid outcome and much more careful research is needed to sort out why some people are able to recover from Covid and others succumb to it.

The same clusters of complexity will apply when The Heartland Study science team looks for connections between herbicide exposures and birth outcomes in the mother-infant pairs moving through our research protocol.

Challenges Unique to The Heartland Study

The two basic measures at the heart of The Heartland Study— “Adverse Birth Outcomes” and “Index of Prenatal Herbicide Exposures” — will require complex calculations and methodological breakthroughs. No one has cracked these nuts before, but it is time to tap modern science in a fresh effort to do so.

The Heartland Study is focused on two primary adverse reproductive outcomes: failure to conceive and pregnancy loss (aka spontaneous abortion or miscarriage). Plus, we will look for links between prenatal herbicide exposures and several adverse birth outcomes ranging from common outcomes like preterm delivery of low birth-weight babies, to birth defects and developmental delays, learning disabilities and behavioral problems as children grow up. How we plan on doing so is explained in our four-year protocol.

On the exposure side of The Heartland Study equation, our team faces a bushel of challenges. First, herbicide use and exposures are rapidly changing. Can we collect and analyze data fast enough to keep up with changing public health outcomes?

Pregnant women and children in the Heartland are exposed to several herbicides at varying levels nearly year round. These herbicides vary in toxicity by orders of magnitude, and might be interacting in ways science has not recognized. Creating an integrated measure of exposure across multiple herbicides is going to be a difficult challenge.

We also expect exposure levels and impacts to vary depending on where women live (out in farm country where herbicide use is widespread and nearby) or in cities and suburbs. We also expect variability between the heavy herbicide spray season (April-August) and the little-or-no spraying season (November through March). Such variability poses challenges, but also opportunities to sort out the factors most strongly influencing adverse birth outcomes.

Heartland Study science will be accepted as credible only to the extent we can come up with clear, robust and accurate measures of adverse outcomes and herbicide exposure. We know this task will be more challenging than measuring obesity rates and Covid deaths at the country level.

But we have access to powerful new tools like genetic sequencing and metabolomics to integrate with other cutting-edge experimental systems and our vital, clinical data on what we hope will become 2,000 mother-infant pairs. Where will each MIP each fall in the above graph? Will new insights emerge from the patterns revealed?

Our search for pattern is underway. The endgame is new ability to recognize which herbicides farmers need to move away from so a crop of healthy new Americans will hit the ground running every year across the Heartland.

 

 

Back To Top