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Genotoxicity Assays Published since 2016 Shed New Light on the Oncogenic Potential of Glyphosate-Based Herbicides

Archived HHRA News Posts
  • Eaters Deserve More Complete Information About Nutrition and Health Impacts on Food Labels  

    Multiple lines of evidence point to consumer food choices as major contributors to diet-related disease, and poor health and fitness. In a peer-reviewed journal article published today, authors Chuck Benbrook and Robin Mesnage cite studies indicating that “Some 90% of the estimated USD 4.3 trillion in annual health care costs in the US is triggered or made worse by poor food quality and diet-related disease.” Benbrook is the founder and former executive director of the Heartland Health Research Alliance (HHRA). The authors recommend novel metrics on both the nutrient density of food, and how to more accurately and usefully characterize the degree of food processing and its impacts on public health. The article is open access in the journal Foods and entitled “Enhanced Labeling to Promote Consumption of Nutrient Dense Foods and Healthier Diets.” The core nutrient density metric is a ratio: the percent of daily nutrient needs satisfied by a serving of food relative to the percent of a 2000 calorie daily diet taken up by the serving of food. This single metric is unmatched in comprehensively reflecting the nutritional quality of food. A graphic option to convey the metric on packaging is presented in Figure 3 in the new paper: A novel graphic is presented in Figure 5 to which integrates both the nutrient density and food processing metrics and graphics in a single graphic, shown below. The impacts of ultra-processed food (UPF) on public health outcomes is among the hottest topics in nutrition, medical, and public health journals, and media coverage on food quality and health outcomes. At the request of the journal, the authors developed a video abstract that explains the paper’s goals, methods, and key findings and recommendations. The authors conclude their paper with these observations: Transparent and accurate food product-specific ingredient and nutrient composition data should determine the content of nutrition health labeling. Efforts to soften the message should be resisted in light of the overwhelming need for new food labels that help bring about substantial improvements in food nutritional quality and dietary choices. Benbrook and Mesnage’s paper builds on public comments HHRA submitted in response to the US Food and Drug Administration (FDA) proposed rule in 2023 to update the definition of the term “healthy” on food labels. The proposed role would require foods labeled “healthy” to contain minimum amounts of foods recommended by USDA’s Dietary Guidelines, and to limit saturated fat, sodium, added sugar and other less healthy nutrients. Entitled “Food Labeling: Nutrient Content Claims; Definition of Term `Healthy’”, the comments recommended new  nutrition/health messaging on the front of food packaging. Co-authors of comments included the chair of HHRA’s Policy Advisory committee Dr. Kathleen Merrigan, HHRA science advisors, and other experts working on how changes in farming systems and technology can increase the nutritional quality of food: Dr. Hannah Flower, Dr. Donald R. Davis, Dr. David Montgomery and Anne Biklé. In the comments, the authors introduced “NuCal” as a name for their new system. Resources HHRA February 2023 comments to the FDA. Benbrook and Mesnage (2024). Enhanced Labeling to Promote Consumption of Nutrient Dense Foods and Healthier Diets, Foods. https://doi.org/10.3390/foods13213377 Video Abstract: “Enhanced Labeling to Promote Consumption of Nutrient Dense Foods and Healthier Diets”

  • HHRA Weighs in on Key Pesticide Issues Under Review by the National Organic Standards Board

    HHRA and ORG-Tracker, represented by Dr. Chuck Benbrook and Dr. Brian Baker, submitted comments to the Agricultural Marketing Service at the USDA in advance of the National Organic Standards Board (NOSB) meeting in Portland, Oregon, from October 22nd to 24th, 2024. Drs. Benbrook and Baker will both attend the conference and deliver public comments. ORG-Tracker is a project carried out by HHRA. It aggregates pesticide residue data from inspections of organic farms carried out by certifiers. The tables generated by ORG-Tracker utilize the results of certifier testing to compare residue frequency and risk levels to food produced on conventional farms. The team is working to more effectively highlight gaps and challenges faced by certification agencies to answer questions like What crops should we be testing, and where? Is a pesticide residue found in an organic sample likely caused by accident, pesticide drift, or an intentional and illegal application? How can we modify organic programs to better mitigate risk? The comments delivered to the USDA discuss risk-based certification, pesticide residue testing, and policies impacting the incorporation of so-called inert ingredients in the biopesticides approved for use on organic farms. They argue for a more rigorous, comprehensive, and health-focused approach to risk oversight. Regarding residue testing, they advocate for more expansive and effective data aggregation to inform consumers and the organics community. Finally, for inert ingredients, they recommend further review of current policy, including increased transparency of ingredients in pesticide products. Thank you to Drs. Benbrook and Baker for your advocacy and hard work!   The three sets of comments are posted on HHRA’s website as part of our policy program: Comments to the NOSB on the Risk-Based Certification Discussion Document Under Consideration During the October 2024 Meeting in Portland, Oregon Written Comments on the NOSB Discussion Document “Residue Testing for the Global Supply Chain” Comments on the Inert Ingredients in Organic Pesticide Products Proposal dated August 13, 2024   Drs. Benbrook and Baker also submitted and presented comments at the Spring 2024 meeting of the NOSB, which are available on HHRA’s Policy and Regulatory Reform page.

  • Dr. Kimberly Yolton joins HHRA board

    Dr. Yolton is a developmental psychologist and epidemiologist serving as Professor of Pediatrics at Cincinnati Children’s Hospital Medical Center. Her interests include exposures and experiences that may alter a child’s developmental trajectory from infancy through adolescence. She collaborates on research projects on typical child development as well as those focused on the impact of exposures to environmental toxicants, opiates and stress during early development.

  • Paul Hartnett, HHRA’s Executive Director

      Paul Hartnett has served as HHRA’s CFO since our founding . With the departure of Russell King, Paul has now joined the board and Executive Director. We thank Russell for his service and wish him the best in his future endeavors.

  • Heartland Study Enrolls 1,000th Mother-Infant Pair

    July 19, 2024 – In June of this year, the Heartland Study achieved a major milestone, enrolling its 1,000th mother-infant pair. Enrollment is now at 50% of goal. The objective of the Study is to help fill major gaps in our understanding of the impacts of herbicides on maternal and infant health. Currently in Phase 1, the Study is focused on evaluating associations between herbicide concentrations in body fluids and tissue samples from pregnant women and infants, and pregnancy/childbirth outcomes. Phase 2 is designed to evaluate potential associations between herbicide biomarkers and early childhood neurological development. Much appreciation for the mothers enrolled, and the entire Heartland Study Team including scientists, support staff and clinicians for this tremendous achievement, and for our funders to making this work possible. Read more about the study including peer-reviewed studies published in Chemosphere and Agrichemicals at our publications  page. The investment required to conduct this study exceeds $1 million each year. You can support this important work by making a donation here.

Genotoxicity Assays Published Since 2016 Shed New Light on the Oncogenic Potential of Glyphosate-Based Herbicides

Jan 16th, 2023
Jan 16th, 2023
Genotoxicity Assays Published since 2016 Shed New Light on the Oncogenic Potential of Glyphosate-Based Herbicides

Is DNA Damaged When Applicators are Exposed to Glyphosate-Based Herbicides? An HHRA Scientist Wanders Deep in the Weeds

Glyphosate-based herbicides (GBHs) have been used since 1974. The first evidence that GBHs can damage DNA was published in the 1990s. By then, Monsanto had submitted to the US EPA and other regulators around 100 genotoxicity studies, 99 of which reported no evidence of a positive genotoxic response.

These ~99 negative studies, coupled with Monsanto-commissioned critiques of the design, quality, and interpretation of the relatively few published, positive assays, convinced regulators that glyphosate and GBHs were not genotoxic.

From 2000-2010 a few dozen more scientific papers reported a positive genotoxicity response following exposure to glyphosate or a GBH. Several dozen more assays have been published since, with over 70% reporting a positive response.

Despite substantial new evidence showing glyphosate and GBHs can damage DNA and do so through at least two mechanisms of action, EPA and other regulators have not budged from their early 1990s conclusion.

Why is This Important?

Because GBHs are by far the most widely and heavily applied pesticide in history. Worldwide and in the US, more people have and continue to apply GBHs than any other pesticide. A significant share of people applying Roundup or another GBH do so with small-scale, handheld spray equipment that sometimes leads to high levels of dermal exposure to spray solution.

Over 130,000 Americans who have applied Roundup brand GBHs are now suffering from non-Hodgkin lymphoma (HNL) and have sued Monsanto (now owned by Bayer) for damages because of the lack of warnings on Roundup labels, defective, unsafe product design, and inadequate label directions and requirements.

The Roundup-NHL litigation is ongoing, although over 90,000 of the 130,000+ cases have settled and resulted in over $11 billion in payments to individual plaintiffs.

Dozens, if not hundreds of new cases are bound to arise annually over the next two or more decades. Why? Because some 65,000 people are newly diagnosed with NHL each year, and some portion of them will be among the millions of people who regularly spray Roundup to control weeds around homes, gardens, schools, roadways, industrial facilities, canals, power lines, and farm fields.

Science on Trial

Courts and juries have been wrestling for six years now over whether Roundup is more likely than not to increase the risk of NHL among applicators who used the herbicide many times annually over several years.

The debate among dueling lawyers and experts varies from trial to trial, but a primary focus in all trials has been on whether available science supports a “more likely than not” connection between heavy Roundup use and NHL.

Big differences exist in how GBH manufacturers and the US EPA assess the capacity of glyphosate and GBHs to damage DNA (they both conclude it does not), compared to the International Agency for Research on Cancer (IARC) and many scientists not working for or on behalf of GBH manufacturers (it does damage DNA via at least two mechanisms of action).

Controversy over the safety of Roundup and other GBHs has stimulated new research. In the last seven years, 84 newly published assays have reported a genotoxic response following exposure to glyphosate or a GBH, while just six published assays have reported no evidence of such a response.

Genotoxicity Assays Published since 2016 Shed New Light on the Oncogenic Potential of Glyphosate-Based Herbicides

This is among the key findings in an open-access paper by Charles Benbrook, HHRA’s Executive Director, Robin Mesnage, and William Sawyer. “Genotoxicity Assays Published Since 2016 Shed New Light on the Oncogenic Potential of Glyphosate-Based Herbicides” was published in the new journal Agrochemicals on January 16, 2023.

Agrochemicals In The NewsAll three co-authors have worked with plaintiff attorneys on the Roundup-NHL litigation. This has helped them understand how and why the EPA and other regulators have thus far not acknowledged that the weight-of-evidence has now shifted.

As stated in the last sentence in the paper’s abstract, “In light of genotoxicity results published since 2015, the conclusion that GBHs pose no risk of cancer via a genotoxic mechanism is untenable.”

It can take a lot of new science to convince regulators to change a conclusion they have defended for 40 years. Will the new data reported in this paper draw regulators deep enough into the weeds to understand that GBHs do indeed pose cancer risk through genotoxic mechanisms of action?  Time will tell.

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