Project Bibliography

Bibliographies Grouped by Tag:
24 D | Adjuvants | Agricultural Health Study | AMPA | Analytical Methods | Atrazine | Biomonitoring | Birth Cohort Studies | Birth Defects | Birthweight | Cancer Risks | Chlorpyrifos | Crop Science | Cumulative Toxicity | Cypermethrin | Cytotoxicity | Desiccation | Developmental Impacts | Dicamba | Dicamba Part I | Dicamba Part II | Dicamba Part III | Dicamba Watch | Dietary Risk | Diversified Weed Management/Integrated Pest Management (IPM) | Economics | Endocrine Disruptors | Endosulfan | Environmental Impacts | Epidemiological Studies | Epigenetic Impacts | Ethics and Environmental Justice | Exposure at School and Public Spaces | Exposure in Pets | Female Reproductive Impacts | Full Text Available | Gastrointestinal Impacts | Genotoxicity | Gestational Length | Glufosinate | Glyphosate | Heartland Region | Herbicide Industry Labels and User Guides | Herbicide Use | Imidacloprid | Insecticides | Kidney Disease | Liver Damage | Lowdown on Roundup Part I | Lowdown on Roundup Part II | Lowdown on Roundup Part III | Lowdown on Roundup Part IV | Male Reproductive Impacts | Meta-Analysis or Review Paper | Metolachlor | Microbiome | Miscarriage Rate | Neonicotinoids | Neurodevelopmental Toxicity | Occupational Exposure | Organophosphates | Other Health Risks | Oxidative Stress | Paraquat | Pesticide Residues | Pesticide Use | Policy and Politics | Pregnancy | Remediation | Resistant Weeds | Risk Assessment | Roundup | Routes of Exposure | Science Team Publication | Weed Management Systems
Combine bibliography tags from the above list:

Macfarlane et al., 2013

Macfarlane, E., Carey, R., Keegel, T., El-Zaemay, S., & Fritschi, L.; “Dermal exposure associated with occupational end use of pesticides and the role of protective measures;” Safety and Health at Work, 2013, 4(3), 136-141; DOI: 10.1016/


BACKGROUND: Occupational end users of pesticides may experience bodily absorption of the pesticide products they use, risking possible health effects. The purpose of this paper is to provide a guide for researchers, practitioners, and policy makers working in the field of agricultural health or other areas where occupational end use of pesticides and exposure issues are of interest.

METHODS: This paper characterizes the health effects of pesticide exposure, jobs associated with pesticide use, pesticide-related tasks, absorption of pesticides through the skin, and the use of personal protective equipment (PPE) for reducing exposure.

CONCLUSIONS: Although international and national efforts to reduce pesticide exposure through regulatory means should continue, it is difficult in the agricultural sector to implement engineering or system controls. It is clear that use of PPE does reduce dermal pesticide exposure but compliance among the majority of occupationally exposed pesticide end users appears to be poor. More research is needed on higher-order controls to reduce pesticide exposure and to understand the reasons for poor compliance with PPE and identify effective training methods.


Baldi et al., 2006

Baldi, I., Lebailly, P., Jean, S., Rougetet, L., Dulaurent, S., & Marquet, P.; “Pesticide contamination of workers in vineyards in France;” Journal of Exposure Science and Environmental Epidemiology, 2006, 16(2), 115-124; DOI: 10.1038/sj.jea.7500443.


In order to build tools to quantify exposure to pesticides of farmers included into epidemiological studies, we performed a field study in Bordeaux vineyards during the 2001 and 2002 treatment seasons to identify parameters related to external contamination of workers. In total, 37 treatment days were observed in tractor operators corresponding to 65 mixing operations, 71 spraying operations and 26 equipment cleaning. In all, four operators with backpack sprayers and seven re-entry workers were also monitored. We performed both detailed observations of treatment characteristics on the whole day and pesticide measurements of external contamination (dermal and inhalation) for each operation. The median dermal contamination was 40.5 mg of active ingredient per day for tractor operators, 68.8 mg for backpack sprayers and 1.3 mg for vineyard workers. Most of the contamination was observed on the hands (49% and 56.2% for mixing and spraying, respectively). The median contribution of respiratory route in the total contamination was 1.1%. A cleaning operation resulted in a 4.20 mg dermal contamination intermediate between a mixing (2.85 mg) and a spraying operation (6.13 mg). Farm owners experienced higher levels than workers and lower contaminations were observed in larger farms. The contamination increased with the number of spraying phases and when equipment cleaning was performed. Types of equipment influenced significantly the daily contamination, whereas personal protective equipment only resulted in a limited decrease of contamination. FULL TEXT

Lebailly et al., 2009

Lebailly, P., Bouchart, V., Baldi, I., Lecluse, Y., Heutte, N., Gislard, A., & Malas, J. P.; “Exposure to pesticides in open-field farming in France;” Annals of Occupational Hygeine, 2009, 53(1), 69-81; DOI: 10.1093/annhyg/men072.


OBJECTIVES: Identification of parameters associated with measured pesticide exposure of farmers in open-field farming in France.

METHODS: Open-field volunteer farmers were monitored during 1 day use of the herbicide isoproturon on wheat and/or barley during the winters 2001 (n = 9) or 2002 (n = 38) under usual conditions of work. The whole-body method was used to assess potential dermal exposure using coveralls and cotton gloves. Mixing-loading and application tasks were assessed separately with 12 different body areas (hands, arms, forearms, legs, chest, back and thighs) measured for each task (mixing-loading and application separately).

RESULTS: Daily potential dermal exposure to isoproturon ranged from 2.0 to 567.8 mg (median = 57.8 mg) in 47 farmers. Exposure during mixing-loading tasks accounted for 13.9-98.1% of the total exposure (median = 74.8%). For mixing-loading, hands and forearms were the most contaminated body areas accounting for an average of 64 and 14%, respectively. For application, hands were also the most contaminated part of the body, accounting for an average of 57%, and thighs, forearms and chest or back were in the same range as one another, 3-10%. No correlations were observed between potential dermal exposure and area sprayed, duration of spraying or size of the farm. However, a significant relationship was observed between exposure and the type of spraying equipment, with a rear-mounted sprayer leading to a higher exposure level than trailer sprayers. Technical problems, particularly the unplugging of nozzles, and the numbers mixing-loading or application tasks performed were also significantly related with higher levels of exposure.

CONCLUSIONS: The main results obtained in this study on a large number of observation days are as follows: (i) the mixing-loading step was the most contaminated task in open field accounting for two-thirds of the total daily exposure, (ii) no positive correlation was noted with classically used pesticide-related parameters: farm area, area sprayed and duration of application and (iii) relevant parameters were the type of spraying equipment, the type and number of tasks and technical problems or cases of overflowing.  FULL TEXT

Calafat, 2012

Calafat, A. M.; “The U.S. National Health and Nutrition Examination Survey and human exposure to environmental chemicals;” International Journal of Hygiene and Environmental Health, 2012, 215(2), 99-101; DOI: 10.1016/j.ijheh.2011.08.014.


Researchers are increasingly interested in using human biomonitoring – the measurement of chemicals, their metabolites or specific reaction products in biological specimens/body fluids – for investigating exposure to environmental chemicals. General population human biomonitoring programs are useful for investigating human exposure to environmental chemicals and an important tool for integrating environment and health. One of these programs, the National Health and Nutrition Examination Survey (NHANES), conducted in the United States is designed to collect data on the health and nutritional status of the noninstitutionalized, civilian U.S. population. NHANES includes a physical examination, collecting a detailed medical history, and collecting biological specimens (i.e., blood and urine). These biological specimens can be used to assess exposure to environmental chemicals. NHANES human biomonitoring data can be used to establish reference ranges for selected chemicals, provide exposure data for risk assessment, and monitor exposure trends. FULL TEXT

Linhart et al., 2021

Linhart, Caroline, Panzacchi, Simona, Belpoggi, Fiorella, Clausing, Peter, Zaller, Johann G., & Hertoge, Koen; “Year-round pesticide contamination of public sites near intensively managed agricultural areas in South Tyrol;” Environmental Sciences Europe, 2021, 33(1); DOI: 10.1186/s12302-020-00446-y.


BACKGROUND: In a previous study, we found that 45% of public playgrounds near intensively managed agricultural areas were contaminated with mainly endocrine active pesticide residues in spring. Here, we investigated potential contamination over the course of a year.

METHODS: Residue data were analyzed from 96 grass samples collected in spring, summer, autumn, and winter by the South Tyrolean Medical Service in 19 public playgrounds, four schoolyards, and one marketplace located within intensively managed agricultural landscapes. Samples were analyzed for 281 substances using gas-chromatography and mass-spectrometry.

RESULTS: A total of 32 pesticide residues and one preservative agent were found. Almost all of the sites (96%) were contaminated with at least one residue during the year; in 79% of the sites, more than one residue was found. Among the detected residues, 76% are classified as endocrine active substances, with the highest concentrations of the insecticide chlorpyrifos-methyl (0.71 mg kg−1), the herbicide oxadiazon (0.64 mg kg−1), and the fungicides captan (0.46 mg kg−1) and fluazinam (0.23 mg kg−1). The number of residues, their concentrations, and the proportion of contaminated sites varied across seasons (p < 0.001). Twenty-five residues were found in 83% of the sites in spring (median concentration 0.240 mg kg−1), nine in 79% of the sites in summer (0.092 mg kg−1), three in 50% of the sites in autumn (0.076 mg kg−1), and four in 17% of the sites in winter (0.155 mg kg−1). Playgrounds already examined in 2017 in the previous study, were more often contaminated with multiple pesticide residues in 2018 (p = 0.045).

CONCLUSION: This study confirms previous findings of widespread pesticide contamination of public sites within intensively managed agricultural areas. Moreover, pesticide residues were also found in periods with little or no pesticide application in the field (autumn and winter). It is worrisome that many of the detected residues are endocrine active substances and that some of them (thiacloprid, bupirimate, captan, folpet) are “suspected human carcinogens”, according to EU authorities. Thus, we call for more effective controls of pesticide applications to minimize pesticide drift into public places. FULL TEXT

Lamichhane, 2017

Lamichhane, Jay Ram; “Pesticide use and risk reduction in European farming systems with IPM: An introduction to the special issue;” Crop Protection, 2017, 97, 1-6; DOI: 10.1016/j.cropro.2017.01.017.


Not available.


Epstein and Zhang, 2014

Epstein, Lynn, & Zhang, Minghua. (2014). The Impact of Integrated Pest Management Programs on Pesticide Use in California, USA. In R. Peshin & D. Pimentel (Eds.), Integrated Pest Management (pp. 173-200): Springer.


Integrated Pest Management (IPM) is often promoted to farmers as a method that can provide the most economical, sustained disease and pest control, but promoted to the public as a method to reduce agricultural pesticide use. California has a public infrastructure for supporting IPM research and implementation, largely through the University of California IPM program. California’s Department of Pesticide Regulation’s Pesticide Use Reports provide a system to track pesticide use state-wide. In practice, IPM in California is extremely pesticide-dependent, particularly in weed control and in agricultural production systems that rely on soil fumigation, such as strawberries. During our study period between 1993 and 2010, California had a decrease in use of 88 % of the highly-used pesticides listed for regulatory concern for human health. However, most of these pesticides were replaced with other chemicals rather than with non-chemical methods. We feature several case studies that illustrate key issues in California IPM: the limited progress in meeting Montreal Protocol guidelines for methyl bromide phase-out due to critical use exemptions for strawberry producers; a successful IPM program to decrease use of dormant-season organophosphates that are important water pollutants; the increase in use of neonicotinoid insecticides, which might have a role in the current bee colony collapse disorder; and the limited use of all of the commercialized microbial biocontrol agents except for Bacillus thuringiensis. FULL TEXT

Zhang et al., 2019b

Zhang, J., Huang, Y., Reddy, K. N., & Wang, B.; “Assessing crop damage from dicamba on non-dicamba-tolerant soybean by hyperspectral imaging through machine learning;” Pest Management Science, 2019, 75(12), 3260-3272; DOI: 10.1002/ps.5448.


BACKGROUND: Dicamba effectively controls several broadleaf weeds. The off-target drift of dicamba spray or vapor drift can cause severe injury to susceptible crops, including non-dicamba-tolerant crops. In a field experiment, advanced hyperspectral imaging (HSI) was used to study the spectral response of soybean plants to different dicamba rates, and appropriate spectral features and models for assessing the crop damage from dicamba were developed.

RESULTS: In an experiment with six different dicamba rates, an ordinal spectral variation pattern was observed at both 1 week after treatment (WAT) and 3 WAT. The soybean receiving a dicamba rate >/=0.2X exhibited unrecoverable damage. Two recoverability spectral indices (HDRI and HDNI) were developed based on three optimal wavebands. Based on the Jeffries-Matusita distance metric, Spearman correlation analysis and independent t-test for sensitivity to dicamba spray rates, a number of wavebands and classic spectral features were extracted. The models for quantifying dicamba spray levels were established using the machine learning algorithms of naive Bayes, random forest and support vector machine.

CONCLUSIONS: The spectral response of soybean injury caused by dicamba sprays can be clearly captured by HSI. The recoverability spectral indices developed were able to accurately differentiate the recoverable and unrecoverable damage, with an overall accuracy (OA) higher than 90%. The optimal spectral feature sets were identified for characterizing dicamba spray rates under recoverable and unrecoverable situations. The spectral features plus plant height can yield relatively high accuracy under the recoverable situation (OA = 94%). These results can be of practical importance in weed management. (c) 2019 Society of Chemical Industry.


Cuyno, 2001

Cuyno, L.; “Economic analysis of environmental benefits of integrated pest management: a Philippine case study;” Agricultural Economics, 2001, 25(2-3), 227-233; DOI: 10.1111/j.1574-0862.2001.tb00203.x.


Health and environmental concerns associated with pesticide use have motivated the development of integrated pest management (IPM) programs around the world. Little empirical work has been completed to estimate the value of the environmental benefits of IPM. This paper provides an approach to evaluate a broad set of such benefits for a vegetable program in the Philippines. Assessments were made of (1) IPM-induced reduction in environmental risks posed by pesticides in onion production in the Central Luzon and (2) willingness to pay to reduce those risks. The latter was based on a contingent valuation (CV) interview survey of 176 farmers. Risks to humans, birds, aquatic species, beneficial insects, and other animals were considered. IPM practices on onions reduced the use of specific pesticides from 25 to 65%, depending on the practice, and the projected adoption of IPM practices varied from 36 to 94%. Estimated economic benefits varied from 231 to 305 pesos per person per cropping season (40 pesos = 1 US$). The aggregate value of environmental benefits for the five villages where the IPM research program was centered was estimated at 150,000 US$ for the 4600 local residents. Assessment of environmental benefits can help in designing public policies and regulations, and in justifying support for publicly funded IPM programs.  FULL TEXT

Baker et al., 2019

Baker, S. E., Serafim, A. B., Morales-Agudelo, P., Vidal, M., Calafat, A. M., & Ospina, M.; “Quantification of DEET and neonicotinoid pesticide biomarkers in human urine by online solid-phase extraction high-performance liquid chromatography-tandem mass spectrometry;” Analytical and Bioanalytical Chemistry, 2019, 411(3), 669-678; DOI: 10.1007/s00216-018-1481-0.


Neonicotinoid insecticides are widely used replacements for organophosphate and carbamate insecticides, but the extent of human exposure is largely unknown. On the other hand, based on urinary concentrations of DEET metabolites, human exposure to N,N-diethyl-m-toluamide (DEET) appears to be widespread. We developed a fast online solid-phase extraction high-performance liquid chromatography-isotope dilution tandem mass spectrometry (HPLC-MS/MS) method to measure in 200 muL of human urine the concentrations of six neonicotinoid biomarkers (acetamiprid, N-desmethyl-acetamiprid, clothianidin, imidacloprid, 5-hydroxy-imidacloprid, thiacloprid), and two DEET biomarkers (3-diethyl-carbamoyl benzoic acid, 3-ethyl-carbamoyl benzoic acid). Limits of detection ranged from 0.01 to 0.1 mug/L, depending on the biomarker. Accuracy ranged from 91 to 116% and precision ranged from 3.7 to 10 %RSD. The presented method can be used to increase our understanding of exposure to neonicotinoid insecticides and DEET, and to evaluate the potential health effects from such exposures.  FULL TEXT